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KMID : 0357319920270010087
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Journal of the Korean Society for Microbiology
1992 Volume.27 No. 1 p.87 ~ p.92
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Detection of Hepatitis B Virus DNA in Serum by Dot Blot Hybridization
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서민호
서성일/백원기/아상숙/김재룡.
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Abstract
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A total of 149 HBs Ag positive and 15 normal serum samples were tested for the detection of Hepatitis B virus(HBV) DNA to evaluate the relationship between serum HBV DNA positiviby by DNA blot hybridization and serological markers positivity by
ELISA.
Twenty-seven(79.4%) of 34 patients positive for both HBs Ag and HBe Ag were positive for HBV DNA compared with 33(28.7%) of 115 HBs Ag positive but HBe negative individuals.
In addition, among all patients positive for HBV DNA, there was a statistically significant correlation between the concentration of HBV DNA in serum and the presence or absence of HBe Ag.
None of the 15 HBs Ag negative individuals tested was for HBV DNA. But the detection rate of HBV DNA in the cases of HBe Ag negative was as high as 28.7%(33/115), so we concluded that detection of both HBe Ag and HBV DNA should be necessary in
order to
Evaluate the infectivity of the HBs Ag positive sera.
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KEYWORD
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